NFL Week 4 Odds and Betting Lines: Money Likes Rams on the Road on Monday Night Football

The 49ers opened as 2.5-point favorites over the defending Super Bowl champion Rams but money on Los Angeles has trimmed that to San Francisco -1.5. More drastically, the total has plummeted from 47 at open to 42.5 as of Sunday evening.

The first Monday of October sees the Los Angeles Rams visit the San Francisco Giants to close out Week 4 of the NFL schedule.

The Rams are underdogs but only slightly. And as money has poured in on Los Angeles throughout the week, the line has narrowed by Sunday evening.

Here’s a look at the latest NFL Week 4 odds and the notable line moves to point spreads and Over/Under totals.

NFL Week 4 Odds
These are the NFL odds for Week 4, headlined by Stafford and the Rams sitting as 2-point road dogs against San Francisco on Monday Night Football.

Matchup Time Spread Over/Under
Dolphins at Bengals Thurs, 8:15 p.m. ET Bengals -3.5 48
Vikings at Saints* Sun, 9:30 a.m. ET Saints +4 42
Browns at Falcons Sun, 1 p.m. ET Falcons +1 48
Bills at Ravens Sun, 1 p.m. ET Ravens +3 51
Commanders at Cowboys Sun, 1 p.m. ET Cowboys -3 41
Seahawks at Lions Sun, 1 p.m. ET Lions -3.5 47.5
Chargers at Texans Sun, 1 p.m. ET Texans +6 45
Titans at Colts Sun, 1 p.m. ET Colts -3.5 43
Bears at Giants Sun, 1 p.m. ET Giants -2.5 38.5
Jaguars at Eagles Sun, 1 p.m. ET Eagles -6.5 45.5
Jets at Steelers Sun, 1 p.m. ET Steelers -3.5 41.5
Cardinals at Panthers Sun, 4:05 p.m. ET Panthers -1 43.5
Patriots at Packers Sun, 4:25 p.m. ET Packers -9.5 40
Broncos at Raiders Sun, 4:25 p.m. ET Raiders -3 45
Chiefs at Buccaneers Sun, 8:20 p.m. ET Buccaneers -1 46
Rams at 49ers Mon, 8:15 p.m. ET 49ers -1.5 42.5

Odds courtesy of DraftKings as of October 3, 2022
*This game will be played on a neutral field.

Source: https://www.covers.com/nfl/week-4-odds